Uterine artery embolization (UAE) in the UAE

By Jamal Al Deen Alkoteesh, AuntMinnie.com contributing writer, Maysam T. Abu Sa'a, AuntMinnie.com contributing writer, Haleema P. Saripada, AuntMinnie.com contributing writer

Uterine artery embolization (UAE), an outstanding evolution in women's health in the current century, has become an established noninvasive, safe, and effective alternative to conventional surgical treatment for symptomatic uterine fibroids, the most common gynecological benign tumor.1,2,3,4

UAE was introduced in the United Arab Emirates several years ago in conjunction with ongoing major advancements in the development of healthcare services in general and the expansion of interventional and women's health services in particular.5

Uterine artery embolization

The procedure

There has been increasing global interest in uterine artery embolization as the primary management tool for symptomatic uterine fibroids since the first report in 1995 by Ravina et al.6,7 The principle of UAE is to devascularize the uterine fibroids so as to induce irreversible ischemic injury that leads to necrosis and shrinkage of fibroids.8,9

This is achieved by selective catheterization of both uterine arteries under image guidance and injection of embolization particles.10 Polyvinyl alcohol (PVA) particles are commonly used, but the optimal type and size of the embolization particles is an ongoing debate.11 It is suggested to use particles larger than 300 µm to avoid untargeted ovarian embolization and uterine necrosis.12

Embolization materials

Embolization materials used during a single uterine fibroid embolization procedure at Al Ain Hospital in May 2014. All images courtesy of Dr. Jamal Alkoteesh. Safety and efficacy

The safety and efficacy of uterine artery embolization has been extensively described in the literature. The overall technical success was estimated to be up to 95%.7 Numerous publications have reported not only successful control of symptoms following UAE, but also significant symptom improvement in long-term follow-up when compared to abdominal myomectomy.13,14,15,16,17 Moreover, UAE has a shorter recovery period and minimal blood loss when compared to hysterectomy and myomectomy.7,18

Target population

It is proposed that most women with symptomatic uterine fibroids may be suitable candidates for UAE unless contraindicated.1,19 However, careful individualized assessment of patients by both gynecologists and interventional radiologists remains the cornerstone of decent practice.

Absolute contraindications are current pregnancy, known or suspected gynecological malignancy, and submucosal intracavitary and subserosal pedunculated fibroids which may detach, necessitating surgical intervention.10,20 Conversely, relative contraindications include concurrent gonadotropin-releasing hormone (GnRH) agonist therapy, coagulopathy, severe contrast allergy, renal impairment, immunocompromise, previous pelvic irradiation or surgery, and chronic endometritis or a partially treated pelvic infection.10

Uterine artery embolization in the UAE

Uterine artery embolization was introduced in Abu Dhabi, the capital of UAE, in 2009 by Dr. Jamal Alkoteesh, chairman and chief of interventional radiology at Tawam and Al Ain Hospitals. He has managed within three years to establish one of the busiest fibroid clinics in the Middle East, based at Al Ain Hospital (AAH).

Team led by Dr. Jamal Alkoteesh Team led by Dr. Jamal Alkoteesh at Al Ain Hospital during an embolization procedure. We are performing more than 100 cases per year and receiving referrals from countries in the Gulf Cooperation Council (GCC) and elsewhere in the Middle East. Furthermore, many patients are referring themselves to the AAH fibroid clinic after finding about the procedure through the Internet or their physicians.

The procedure has also been made available in almost all major hospitals in Abu Dhabi. This has led to a major advancement in the quality of health services delivered to female patients in the UAE by Abu Dhabi Health Services (SEHA) hospitals.

All cases are discussed at multidisciplinary team meetings within the gynecology department before the embolization procedures are performed. Many gynecologists in the UAE have started to offer uterine artery embolization as a treatment option to their fibroid patients during consultation and when discussing additional treatment options.

Patient preparation

Patients with symptomatic uterine fibroids are being referred to interventional radiology clinics for further assessment and management plans. Patient details, clinical history, physical examination, and imaging and laboratory results are reviewed. The procedure is explained to all patients and informed consent is obtained. All patients are made aware of what to expect from the procedure, its success rate, the risk of failure, complications, and available alternatives.